Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins

• Jiang-Song Zhai and
• Da-Ming Du

Beilstein J. Org. Chem. 2022, 18, 25–36, doi:10.3762/bjoc.18.3

• through a gram-scale synthesis, one-pot three-component reactions and further transformation experiments of the products. Keywords: asymmetric catalysis; cyclization reaction; Michael addition; one-pot three-component reaction; spirobarbiturates; Introduction Indane scaffolds exist in various

• yields and excellent diastereo- and enantioselectivities (up to >99% yield, >20:1 dr and >99% ee). In addition, a gram-scale synthesis, one-pot three-component reactions and further transformation experiments of the products were also demonstrated with excellent stereoselectivities. We believe that the

New highlights of the syntheses of pyrrolo[1,2-a]quinoxalin-4-ones

• Emilian Georgescu,
• Alina Nicolescu,
• Florentina Georgescu,
• Florina Teodorescu,
• Daniela Marinescu,
• Ana-Maria Macsim and
• Calin Deleanu

Beilstein J. Org. Chem. 2014, 10, 2377–2387, doi:10.3762/bjoc.10.248

• Bucharest, Romania Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41-A, RO-700487 Iasi, Romania Research Dept., Teso Spec SRL, Str. Muncii 53, RO-915200 Fundulea, Calarasi, Romania 10.3762/bjoc.10.248 Abstract The one-pot three-component reactions of 1

• . Keywords: 1,3-dipolar cycloadditions; multicomponent; one-pot three-component reactions; pyrrolo[1,2-a]benzimidazole; pyrrolo[1,2-a]quinoxalin-4-one; Introduction The pyrrolo[1,2-a]quinoxaline system has significant biological activities and is a subject fo constant interest. This skeleton is a

• towards N-bridged heterocyclic compounds [17][18][19][20] prompted us to investigate the one-pot three-component reactions of various substituted benzimidazoles with alkyl bromoacetates and electron-deficient alkynes in presence of an epoxide. Herein, we report a simple one-pot three-component synthetic